PLASTIC SURGERY

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PLASTIC

EXPLORE A NON-OPIOID PAIN MANAGEMENT OPTION FOR PLASTIC SURGERY RECOVERY.

Some of the most common concerns about surgery are the amount of pain involved and what to expect when recovering. Well-controlled pain can influence your recovery.¹ Everyone experiences pain differently, and your doctor will have a pain management plan that includes different combinations of medications, including opioid and non-opioid options. In addition to managing pain after surgery, the plan is aimed at helping you reach important recovery goals such as moving, walking, eating, and getting back to normal daily activities. Talk to your doctor about a pain management plan that is right for you and your type of surgery. Create your discussion guide now.

Some common plastic surgeries include:

Abdominoplasty and Lipoabdominoplasty
Mammoplasty
Breast reconstruction and more extensive breast surgeries

Abdominoplasty and Lipoabdominoplasty
Mammoplasty
Breast reconstruction and more extensive breast surgeries

Each year up to 2.6 MILLION patients who take opioids to
manage pain after plastic surgery may become persistent opioid users.²

SIDE EFFECTS from opioids can slow down your recovery and may cause nausea, vomiting, and constipation. Opioids may make you feel drowsy or confused.^3,4

40%

Women are 40% MORE LIKELY than men to become long-term users of opioids after surgery.⁵

100 MILLION OPIOIDS go unused by patients every year—these pills can be misused and abused by others.⁶

While many patients may receive opioids after surgery, there are other options for managing pain after surgery that may help you during recovery. That's why it's important to discuss these options with your doctor.

NON-OPIOID EXPAREL PROVIDES LONG-LASTING PAIN RELIEF AFTER SURGERY

EXPAREL is given during surgery as part of an opioid-minimizing approach and controls pain for the first few days after surgery, when you need it most
EXPAREL works by numbing the area of your body where your surgery was performed, unlike opioids, which affect your whole body

In plastic surgeries, patients given EXPAREL^*

Reported less pain⁷

Required fewer opioids^8,9†

Experienced shorter hospital stays⁹

^*Based on clinical studies of surgeries using EXPAREL as an alternative to standard of care.

^†The clinical benefit of the decrease in opioid consumption was not demonstrated in the pivotal trials.

Indication

EXPAREL^® (bupivacaine liposome injectable suspension) is indicated to produce postsurgical local analgesia via infiltration in patients aged 6 years and older and regional analgesia in adults via an interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and an adductor canal block. Safety and efficacy have not been established in other nerve blocks.

Important Safety Information

EXPAREL should not be used in obstetrical paracervical block anesthesia.

In studies in adults where EXPAREL was injected into a wound, the most common side effects were nausea, constipation, and vomiting.

In studies in adults where EXPAREL was injected near a nerve, the most common side effects were nausea, fever, headache, and constipation.

In the study where EXPAREL was given to children, the most common side effects were nausea, vomiting, constipation, low blood pressure, low number of red blood cells, muscle twitching, blurred vision, itching, and rapid heartbeat.

EXPAREL can cause a temporary loss of feeling and/or loss of muscle movement. How much and how long the loss of feeling and/or muscle movement depends on where and how much of EXPAREL was injected and may last for up to 5 days.

EXPAREL is not recommended to be used in patients younger than 6 years old for injection into the wound, for patients younger than 18 years old for injection near a nerve, and/or in pregnant women.

Tell your health care provider if you or your child has liver disease, since this may affect how the active ingredient (bupivacaine) in EXPAREL is eliminated from the body.

EXPAREL should not be injected into the spine, joints, or veins.

The active ingredient in EXPAREL can affect the nervous system and the cardiovascular system; may cause an allergic reaction; may cause damage if injected into the joints; and can cause a rare blood disorder.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

References

Joshi G, Ogunnaike B. Consequences of inadequate postoperative pain relief and chronic persistent postoperative pain. Anesthesiology Clin N Am. 2005;23(1):21-36.
American Society of Plastic Surgeons. Opioid prescribing resources. Published September 9, 2019. Accessed September 24, 2024. https://www.plasticsurgery.org/for-medical-professionals/health-policy/opioid-prescribing-resources.
Little A, Brower K, Keller D, Ramshaw B, Janis JE. A cost-minimization analysis evaluating the use of liposomal bupivacaine in reconstructive plastic surgery procedures. Plast Reconstr Surg. 2019;143(4):1269-1274.
Hah JM, Bateman BT, Ratliff J, Curtin C, Sun E. Chronic opioid use after surgery: implications for perioperative management in the face of the opioid epidemic. Anesth Analg. 2017;125(5):1733-1740.
Pacira Pharmaceuticals, Inc. United States For Non-Dependence: An Analysis Of The Impact Of Opioid Overprescribing in America. [Analysis in the report was based on research conducted by the QuintilesIMS Institute].
Maughan BC, Hersh EV, Shofer FS, et al. Unused opioid analgesics and drug disposal following outpatient dental surgery: a randomized controlled trial. Drug Alcohol Depend. 2016;168:328-334.
Abdelsattar JM, Boughey JC, Fahy AS, et al. Comparative study of liposomal bupivacaine versus paravertebral block for pain control following mastectomy with immediate tissue expander reconstruction. Ann Surg Oncol. 2016;23(2):465-470.
Fiala T. Tranversus abdominis plane block during abdominoplasty to improve postoperative patient comfort. Aesthet Surg J. 2015;35(1):72-80.
Motakef S, Wong WW, Ingargiola MJ, et al. Liposomal bupivacaine in implant-based breast reconstruction. Plast Reconstr Surg Glob Open. 2017;5(11):e1559.